Kadsulignan N

Kadsulignan N, a natural product has anti-HIV activity (EC50: 43.56 μM). Kadsulignan N is also a COX-2 ligand (Ki: 72.24 nM)[1][2].

COX-2

[1] Gao XM, et al. Lignans from Kadsura angustifolia. J Nat Prod. 2008 Apr;71(4):558-63. DOI:10.1021/np0705108
[2] Zhang XY, et al. Discovery of cyclooxygenase-2 inhibitors from Kadsura coccinea by affinity ultrafiltration mass spectrometry and the anti-inflammatory activity. Fitoterapia. 2021 Jun;151:104872. DOI:10.1016/j.fitote.2021.104872