(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate

Chemical Properties

Boiling point	642.9±50.0 °C(Predicted)
Density	1.305±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	DMSO: ≥10mg/mL
pka	12.51±0.46(Predicted)
form	White solid
color	white to tan
InChI	1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChIKey	VMFGCGRAIBLAFY-IBGZPJMESA-N
SMILES	COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23

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Animal Model:	Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) ^[2]
Dosage:	5 g/kg
Administration:	Intraperitoneal injection (i.p.); single dose
Result:	Reduced neutrophil recruitment to the lung alveolar space. Reduced tissue damage. Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils. Lowered the viral load in mice.