AMASTATIN

Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC50 of 0.54 μg/mL for AP-A[1][2].

ChEBI: A tetrapeptide comprising (2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl, L-valyl, L-valyl and L-aspartic acid units joined in sequence

[1] Aoyagi T, et al. Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. J Antibiot (Tokyo). 1978 Jun;31(6):636-8. DOI:10.7164/antibiotics.31.636
[2] Wilkes SH, et al. The slow, tight binding of bestatin and amastatin to aminopeptidases. J Biol Chem. 1985 Oct 25;260(24):13154-62. PMID:2865258