PC 190723

Chemical Properties

Melting point	218 °C
Boiling point	462.3±45.0 °C(Predicted)
Density	1.593±0.06 g/cm3(Predicted)
pka	14.15±0.50(Predicted)
form	Solid
color	Light yellow to yellow
InChI	InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21)
InChIKey	INYJNSBDHOVLAH-UHFFFAOYSA-N
SMILES	C(N)(=O)C1=C(F)C=CC(OCC2=NC3=CC(Cl)=CN=C3S2)=C1F

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Animal Model:	S. aureus treated mice^[1]
Dosage:	30 mg/kg
Administration:	Subcutaneous/intravenous injection; Single dose
Result:	Resulted in a 100% survival of mice inoculated intraperitoneally with a potentially lethal dose of S. aureus, as compared with a 0% survival for the group receiving no compound. Produced dose-dependent efficacy for both routes of administration with ED₅₀ were 7.3 and 10.2 mg/kg for S.C. and I.V. administration, respectively.