CAY10618
CAY10618 性质
| 密度 | 1.15±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：10 mg/ml； DMSO：10 mg/ml； DMSO:PBS(pH 7.2)(1:3)：0.25 mg/ml；乙醇：10 mg/ml |
| 酸度系数(pKa) | 14.80±0.70(Predicted) |
CAY10618 用途与合成方法
Nampt;
Autophagy
GPP78 (Compound 8; 10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes.
GPP78 (Compound 8) inhibits the growth of most cell lines tested, with nanomolar potency (GI
50
) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic.
Western Blot Analysis
| Cell Line: | SH-SY5Y cells |
| Concentration: | 10 nM |
| Incubation Time: | 24 hours, 40 hours |
| Result: | Punctate staining of LC3-II and the formation of autophagolysosomes were observable. |
GPP78 (10 mg/kg; intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment reduces the severity of spinal cord trauma in SCI mice.
| Animal Model: | Male adult CD1 mice (25-30 g) with spinal cord injury (SCI) |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; daily; 1 hour or 6 hours after SCI; for 19 days |
| Result: | Significantly reduced the demyelination associated with SCI. And significantly ameliorated the functional deficits induced by SCI. |
CAY10618 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-14374 | CAY10618 | 1202580-59-3 | 5mg(11.38mM * 1mL in Methanol) | 5400 |
