9-OxoODE-d3

9-OxoODE-d3 contains three deuterium atoms at the 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 9-OxoODE by GC- or LC-mass spectrometry. 9-OxoODE results from oxidation of the allylic hydroxyl of either 9(S)- or 9(R)-HODE. Rabbit reticulocyte plasma and mitochondrial membranes contain both 9- and 13-oxoODEs, representing about 2% of the total linoleate residues in the membranes. Most of these oxidized linoleate residues are esterified to membrane lipids.1,2,3WARNING This product is not for human or veterinary use.

[1] HARTMUT KÜHN  Rainer W  Jutta BELKNER. Subcellular distribution of lipoxygenase products in rabbit reticulocyte membranes*[J]. The FEBS journal, 1990, 191 1: 221-227. DOI: 10.1111/j.1432-1033.1990.tb19113.x
[2] H KÜHN  R W  J Belkner. Metabolism of polyenoic fatty acids by rabbit reticulocytes. Intracellular action of the erythroid lipoxygenase on membrane lipids.[J]. Biomedica biochimica acta, 1990, 49 2-3: S25-30.
[3] H. KÜHN . Occurrence of 9- and 13-keto-octadecadienoic acid in biological membranes oxygenated by the reticulocyte lipoxygenase[J]. Archives of biochemistry and biophysics, 1990, 279 2: Pages 218-224. DOI: 10.1016/0003-9861(90)90484-g