(S)-2-[N'-(N-BENZYLPROLYL)AMINO]BENZOPHENONE

LIGHT YELLOW CRYSTALLINE POWDER

(S)-2-[N'-(N-BENZYLPROLYL)AMINO]BENZOPHENONE can be prepared by condensation of (S)-o-[(N-benzylprolyl)amino]benzophenone (BBP) with glycine in the presence of nickel(II) nitrate in methanol.

(S)-2-[N'-(N-BENZYLPROLYL)AMINO]BENZOPHENONE can be purified by sequential chromatography over silica gel and Sephadex LH-20, or by dry flash chromatography.

care should be taken in applying (S)-2-[N'-(N-BENZYLPROLYL)AMINO]BENZOPHENONE to purified Sephadex. The  addition of basic media can present an explosion hazard.