TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to lydicamycin . It is active against Gram-positive bacteria (MICs = 0.39-3.13 μg/ml), including methicillin-resistant S. aureus strains (MIC = 3.13 μg/ml), but is ineffective against Gram-negative bacteria (MICs = >50 μg/ml).
TPU-0037C, a close structural analogue of lydicamycin, has been shown to be highly active against MRSA. TPU-0037C is also closely related to BN 4515N which was isolated from a strain of Microtetraspora as a neuritogenic agent.
Antibiotic TPU-0037-C is an agent with activity against gram-positive bacteria.
[1] TAMOTSU FURUMAI. TPU-0037-A, B, C and D, novel lydicamycin congeners with anti-MRSA activity from Streptomyces platensis TP-A0598.[J]. Journal of Antibiotics, 2002, 55 10: 873-880. DOI:
10.7164/antibiotics.55.873
