5α-Hydroxy-11-methoxy-1-methyl-9,10-(methylenebisoxy)lycorenan-7-one

This alkaloid possesses a similar structure to that of Nerinine (q.v.) and is found in Nerine krigeii. It may be crystallized from AcOEt and is dextrorotatory with [0:]54 + 161.6° (c 0.57, CHC13). It is hygroscopic and behaves as a monoacidic base yielding a picrate as yellow prisms, m.p. 205-9°C (dec.); a methiodide, m.p. 260-5°C (dec.) and a crystalline O-acetate, m.p. 20t-2°C. It contains a lactone ring which may be opened by alkalies and regenerated by acids.

Briggs et at., J. Arner. Chern. Soc., 78,2899 (1956)
Jeffs, Hawksworth., Tetrahedron Lett., 217 (1963)