Dopamine receptor antagonist
S-()-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments.
Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic.
Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism.
Eticlopride (10 mg/kg, i.p.) hydrochloride blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing mice[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) hydrochloride alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
| Animal Model: | Sprague-Dawley rats treated with Ruinpirole (1 mg/kg) from postnatal days 1 to 21[4] |
| Dosage: | 0.01 or 0.02 mg/kg |
| Administration: | i.p. |
| Result: | Alleviated cognitive deficits produced by neonatal quinpirole treatment in both male and female rats on the place version of the MWT, as well as in males tested on the match-to-place version of the MWT (MWT tested on P22 to P28). |
D2 Receptor: 0.09 nM (Ki)
room temperature (desiccate)
![FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride Structure](/CAS/20211123/GIF/97612-24-3.gif)
