衣霉素
衣霉素 性质
| 熔点 | 234-235℃ (decomposition) |
|---|---|
| 比旋光度 | D20 +52° (c = 0.5 in pyridine) |
| 闪点 | 87℃ |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于甲醇、乙醇、DMSO或DMF |
| 形态 | 白色至类白色固体 |
| 颜色 | 白色 |
| 生物来源 | Streptomyces sp. |
| 敏感性 | Moisture & Light Sensitive |
| BRN | 6888090 |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
| InChIKey | YJQCOFNZVFGCAF-WPTOCQRYSA-N |
| SMILES | N4(C=CC(=O)NC4=O)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(O)C[C@H]2O[C@@H]([C@@H]([C@H]([C@H]2O)O)NC(=O)\C=C\CC(C)C)O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3NC(=O)C)O)O)CO |
| EPA化学物质信息 | Tunicamycin (11089-65-9) |
衣霉素 用途与合成方法
Tunicamycin (2 µg/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression in CD44+/CD24- and original MCF7 cells.
Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation and in vitro invasion and accelerates tumorosphore formation. Under effect of Tunicamycin, the results show that inhibited invasion, increased cell death, suppressed proliferation and reduced migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture.
Western Blot Analysis
| Cell Line: | CD44+/CD24- and original MCF7 cells [1] |
| Concentration: | 2 µg/mL |
| Incubation Time: | 24 hours |
| Result: | Increased level of spliced XBP-1, ATF6 nuclear translocation and CHOP protein expression are detected in CD44+/CD24- and original MCF7 cells. |
Tunicamycin (0.1 mg/kg or 0.5 mg/kg) treatment dramatically suppresses tumor growth in the CD133 +/- MHCC97L cells xenograft model (BALB/c ( nu/nu ) mice).
安全信息
| 危险品标志 | T+,T |
|---|---|
| 危险类别码 | 28 |
| 安全说明 | 28-37/39-45 |
| 危险品运输编号 | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | YO7980200 |
| F | 8-10-18-21 |
| 危险等级 | 6.1(a) |
| 包装类别 | II |
| 海关编码 | 29419090 |
| 存储类别 | 6.1A - 可燃，急性毒性物质（类别1和类别2） 剧毒的危险物质 |
| 危险性类别 | 急性毒性 类别1 经口 |
衣霉素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-06-05 | HY-A0098 | 衣霉素 | 11089-65-9 | 1 mg | 1281 |
| 2026-06-05 | HY-A0098 | 衣霉素 | 11089-65-9 | 2mg | 1925 |
