Tyr-D-Ala-Gly-Phe-Met

Product NameTyr-D-Ala-Gly-Phe-Met
CAS61370-87-4
MFC28H37N5O7S
MW587.69
EINECS
MOL File61370-87-4.mol

Usage And Synthesis

Description

Enkephalin-met, ala(2)- is a synthetic analog of methionine enkephalin.

Uses

[D-Ala2]-Met-Enkephalin, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalin inhibits ACh-induced and suckling-induced oxytocin (OT) release[1][2].

in vivo

[D-Ala2]-Met-Enkephalin (0.01-1μg; ICV; once) inhibits suckling-induced oxytocin (OT) release in lactating mice^[1].

Animal Model:	Lactating rats^[1]
Dosage:	0.01, 0.1 and 1 μg
Administration:	Intracerebroventrical injection
Result:	Inhibited ACh-induced and suckling-induced OT release.

References

[1] Haldar J, et, al. Morphine, β-endorphin and [D-Ala2] Met-enkephalin inhibit oxytocin release by acetylcholine and suckling. 1982 Jul–Aug;3(4):663-8.
[2] Godoy AM, et, al. Modulation of the escape response by [d-Ala2]Met-enkephalin in the crab Chasmagnathus. 1995 Mar;50(3):445-51.