1-(2-Methoxyphenyl)piperazine hydrochloride

95520-98-2

5464-78-8

Procedure for the synthesis of compound 6: In a double necked round bottom flask (RB flask), tert-butyl 4-(2-methoxyphenyl)piperazine-1-carboxylate (Compound 5, 0.600 g, 0.00205 mol, 1 equiv.) was dissolved in ethyl ether (10 mL) followed by addition of ethyl ether hydrochloric acid solution. The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming complete consumption of the raw material, the ether was removed by evaporation under reduced pressure to give a solid product. The solid product was washed with ethyl acetate and then dried to give the final 1-(2-methoxyphenyl)piperazine hydrochloride (compound 6) as a white solid (0.425 g, 90.08% yield).