Histone deacetylase 3 (HDAC3) is a zinc-dependent metalloenzyme and class I HDAC.1,2 It is ubiquitously expressed and localizes primarily to the nucleus but also to the cytoplasm and plasma membrane. HDAC3 forms a complex with nuclear receptor co-repressor (NCOR) and silencing mediator of retinoic thyroid receptors (SMRT) to deacetylate histones and induce transcriptional repression and can be recruited to sites bound by activating transcription factor 2 (ATF2) without NCOR to induce inflammatory gene expression, indicating a role in transcriptional activation.2,3 HDAC3 activity is correlated with various diseases, including cancer, metabolic disorders, autoimmune disorders, neurodegenerative and CNS disorders, and cardiovascular disease.4 Cayman’s HDAC3 (C-Term) Rabbit Monoclonal Antibody (Clone RM439) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
