Clusterin is a secreted heterodimeric glycoprotein.1 It is proteolytically processed to remove a signal peptide and cleave the α and β chains.1,2 This cleavage creates small- and medium-sized isoforms found in the nucleus or cytosol and mitochondria, respectively, and a large-sized isoform composed of α- and β chains linked via disulfide bonds near the center that is secreted outside the cell.2 Clusterin is ubiquitously expressed in tissues and found in physiological fluids. It is a multifunctional protein involved in a wide range of processes, including immune modulation, autophagosome formation, apoptosis, and extracellular matrix remodeling, among others.3 Clusterin is upregulated by cellular stress and acts as an extracellular chaperone and scavenger to prevent protein aggregation. SNPs in CLU, the gene encoding clusterin, are associated with a higher rate of cognitive decline in patients with mild cognitive decline or Alzheimer's disease.4 Clusterin is also associated with inflammatory and cardiovascular diseases, where it has either protective or detrimental effects.2 Cayman's Clusterin (C-Term) Rabbit Monoclonal Antibody (Clone RM437) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
