PAMAM Dendrimer G2.0 Succinamic Acid (water solution)

PAMAM dendrimer G2.0 succinamic acid (PAMAM G2.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini.1 It has 16 surface groups. PAMAM G2.0 succinamic acid is an antagonist for the pore-forming channels anthrax toxin protective antigen 63 (PA63; IC50 = 879 nM) in lipid bilayers.2 It is active against S. aureus.3 PAMAM G2.0 succinamic acid inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.1WARNING This product is not for human or veterinary use.

[1] MAHMOUD KANDEEL. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus[J]. Journal of Medical Virology, 2020, 92 9: 1665-1670. DOI: 10.1002/jmv.25928
[2] GOLI YAMINI E M N Nnanya Kalu. Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study[J]. Toxins, 2016, 8 1. DOI: 10.3390/toxins8110337
[3] YOUSEF ALTAHER M K. Structure-Activity Relationship of Anionic and Cationic Polyamidoamine (PAMAM) Dendrimers against Staphylococcus aureus[J]. Journal of Nanomaterials, 2022, 39 1. DOI: 10.1155/2022/4013016