PAMAM Dendrimer G5.0 Succinamic Acid (water solution)

PAMAM dendrimer G5.0 succinamic acid (PAMAM G5.0 succinamic acid) is a polyamidoamine (PAMAM) dendrimer with succinamic acid termini.1 It is approximately 59 Å in diameter and has 128 surface groups.1,2 PAMAM G5.0 succinamic acid inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells when used at a concentration of 10 µM.1 It is active against S. aureus.3 PAMAM G5.0 succinamic acid encapsulating the anthracycline antitumor antibiotic doxorubicin (Item No. 15007) decreases cell viability in KB epithelial carcinoma cells.4 It does not induce mortality in zebrafish, unlike PAMAM dendrimer G6.0 amine (Item No. 39076) or PAMAM dendrimer G6.0 succinamic acid (Item No. 39123), when used at a concentration of 250 ppm in the tank water.5WARNING This product is not for human or veterinary use.

[1] MAHMOUD KANDEEL. A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus[J]. Journal of Medical Virology, 2020, 92 9: 1665-1670. DOI: 10.1002/jmv.25928
[2] MARINA A. DOBROVOLSKAIA*. Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro[J]. Molecular Pharmaceutics, 2011, 9 3: 382-393. DOI: 10.1021/mp200463e
[3] YOUSEF ALTAHER M K. Structure-Activity Relationship of Anionic and Cationic Polyamidoamine (PAMAM) Dendrimers against Staphylococcus aureus[J]. Journal of Nanomaterials, 2022, 39 1. DOI: 10.1155/2022/4013016
[4] MENGEN ZHANG. Impact of Dendrimer Surface Functional Groups on the Release of Doxorubicin from Dendrimer Carriers[J]. The Journal of Physical Chemistry B, 2014, 118 6: 1696-1706. DOI: 10.1021/jp411669k
[5] JOSEPH B PRYOR S L H Bryan J Harper. Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish.[J]. ACS Applied Nano Materials, 2014: 1947-1956. DOI: 10.2147/ijn.s60220