Cystinyl-bis-glycine is a dipeptide intermediate in the synthesis of oxidized glutathione that is composed of two cysteinylglycine peptides linked by a disulfide bond. It is formed via nonenzymatic oxidation of cysteinylglycine, a glutathione catabolite produced by γ-glutamyl transpeptidase.
ChEBI: An organic disulfide obtained by the oxidation of two Cys-Gly molecules which are then linked via a disulfide bond.
[1] O W GRIFFITH S S T. The apparent glutathione oxidase activity of gamma-glutamyl transpeptidase. Chemical mechanism.[J]. The Journal of Biological Chemistry, 1980, 255 11: 5011-5014.
[2] E M KOZAK S S T. Glutathione-degrading enzymes of microvillus membranes.[J]. The Journal of Biological Chemistry, 1982, 257 11: 6322-6327.