六氢姜黄素
六氢姜黄素 性质
| 熔点 | 80-82℃ |
|---|---|
| 沸点 | 622.6±55.0 °C(Predicted) |
| 密度 | 1.226 |
| 闪点 | 218℃ |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少量）、乙酸乙酯（少量）、DCM、DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.02±0.20(Predicted) |
| 颜色 | 淡黄色低 |
| BRN | 2486876 |
六氢姜黄素 用途与合成方法
|
COX-2
|
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC
50
values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.
Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 µM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.
Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E
2
(PGE
2
) in murine macrophages (RAW 264.7) in a concentration-dependent manner.
Cell Viability Assay
| Cell Line: | HT-29 cells |
| Concentration: | 0 µM, 5 µM, 10 µM, 25 µM |
| Incubation Time: | 24 hours or 48 hours |
| Result: | Significantly decreased the viability of HT-29 colon cancer cells. |
RT-PCR
| Cell Line: | HT-29 cells |
| Concentration: | 25 µM |
| Incubation Time: | 24 hours |
| Result: | Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 expression. |
Western Blot Analysis
| Cell Line: | HT-29 cells |
| Concentration: | 25 µM |
| Incubation Time: | 24 hours |
| Result: | Combined with 5-fluorouracil (5-FU; 5 µM) markedly reduced the COX-2 protein. |
Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats.
| Animal Model: | Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH) |
| Dosage: | 50 mg/kg |
| Administration: | Oral administration; daily; for 16 weeks |
| Result: | Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression. |
六氢姜黄素 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-N0929 | 1 mg | 1309 | ||
| 2024-11-08 | HY-N0929 | 六氢姜黄素 | 36062-05-2 | 5mg | 3600 |
