enopeptin A

Enopeptin A is a depsipeptide antibiotic. It is effective against Gram-positive bacteria and Gram-negative bacteria. However, it is not inhibitory to fungi.

Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B, that act by activating and disregulating Clp-family proteins.