Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone found in some fruits fromAnnonaceae family. It is a member of acetogenin class of phytochemicals. It fightsagainst the MDR phenotype of human mammary adenocarcinoma. It has showsantitumor properties by induction of chromatin migration and tumor cellcondensation followed by apoptosis (Oberlies et al. 1997; Desai et al. 2008).