Dioxapyrrolomycin, a tricyclic pyrrole-containing antibiotic
isolated first from Streptomyces fumanus Sveshnikova
in the mid-1980s, displays moderate insecticidal
and acaricidal activity, but systematic structural changes
led to novel synthetic pyrrole derivatives with increased
insecticidal activity and mammalian safety (40). The natural
product and its synthetic congeners are uncouplers of
mitochondrial oxidative phosphorylation.
