amythiamicin D

Amythiamicin D is a thiopeptide antibiotic that inhibits the growth of many Gram-positive bacteria, but not Gram-negative bacteria such as E.coli[1].

[1] Gross S, et al. AmythiamicinD and related thiopeptides as inhibitors of the bacterial elongation factor EF-Tu: modification of the amino acid at carbon atom C2 of ringC dramatically influences activity. ChemMedChem. 2013 Dec;8(12):1954-62. DOI:10.1002/cmdc.201300323