Soluble to 100 mM in DMSO and to 100 mM in ethanol
form
Powder
pka
7.42±0.40(Predicted)
Usage And Synthesis
Uses
Selective μ-opioid receptor antagonist. Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
Biological Activity
Selective μ -opioid receptor antagonist (K i values are 5.4, 244.6 and 2187 nM for μ -, δ - and κ -opioid receptors respectively). Reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.
