verrucarin J

Product Nameverrucarin J
CAS4643-58-7
MFC27H32O8
MW484.54
EINECS
MOL File4643-58-7.mol

Chemical Properties

alpha	D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform)
Boiling point	735.4±60.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
solubility	Dichloromethane: Soluble DMSO: Soluble Ethanol: Soluble Methanol: Soluble
form	powder
color	White

Safety Information

RIDADR	3172
HazardClass	6.1(a)
PackingGroup	I
HS Code	2941900000

Usage And Synthesis

Uses

Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune.

Definition

ChEBI: Verrucarin j is a trichothecene.

in vivo

Verrucarin J (0.5mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model^[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis^[5].

Animal Model:	6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts^[2]
Dosage:	0.5mg/kg body weight
Administration:	i.p. for 4 weeks
Result:	Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.

Animal Model:	Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts^[5]
Dosage:	0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:	i.p. for three weeks after 10 days of injection of A2780 cells
Result:	Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.

References

[1] MINH VAN NGUYEN. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi[J]. Journal of Antibiotics, 2022, 75 9: 514-518. DOI: 10.1038/s41429-022-00541-7
[2] KAREN UDOH. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.[J]. Stem Cell Reviews and Reports, 2019, 15 4: 601-611. DOI: 10.1007/s12015-019-09874-7
[3] DEEKSHA PAL. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer.[J]. ACS Biomaterials Science & Engineering, 2018: 798. DOI: 10.1038/s41419-018-0810-8

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