Tricyclo[3.3.1.13,7]decane-1-carboxamide, N-[4-[(phenylsulfonyl)oxy]phenyl]-

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis[1].

CA Ⅱ: 0.88 μM (IC₅₀); CA Ⅸ: 1.02 μM (IC₅₀); NPP1: 1.36 μM (IC₅₀); NPP2: 1.35 μM (IC₅₀); NPP3: 3.00 μM (IC₅₀)

[1] Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.