DL-Acetylshikonin is a non-selective, reversible cytochrome P450 inhibitor with IC50 values of 1.4-4.0 μM. DL-Acetylshikonin has anti-cancer and anti-inflammatory activities[1].
ChEBI: Acetylshikonin is an acetate ester and a hydroxy-1,4-naphthoquinone.
CYP2C8: 1.4 μM (IC50); CYP2B6: 2.0 μM (IC50); CYP3A: 2.3 μM (IC50); CYP2C19: 2.5 μM (IC50); CYP2D6: 2.5 μM (IC50); CYP2E1: 2.7 μM (IC50); CYP2C9: 3.3 μM (IC50); CYP2J2: 3.3 μM (IC50); CYP2A6: 3.8 μM (IC50); CYP1A2: 4.0 μM (IC50)
[1] Shon JC, et al. Acetylshikonin is a novel non-selective cytochrome P450 inhibitor. Biopharm Drug Dispos. 2017 Dec;38(9):553-556. DOI:
10.1002/bdd.2101
