7-羟基-4-胆甾烯-3-酮
7-羟基-4-胆甾烯-3-酮 性质
| 熔点 | 182-184°C |
|---|---|
| 沸点 | 516.7±29.0 °C(Predicted) |
| 密度 | 1.03±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.49±0.70(Predicted) |
| 颜色 | 白色至类白色 |
7-羟基-4-胆甾烯-3-酮 用途与合成方法
Endogenous Metabolite
Pregnane X receptor (PXR)
7α-Hydroxy-4-cholesten-3-one is found relatively upstream in the biosynthetic pathway to bile acids (e.g. chenodeoxycholic acid). The first step is the incorporation of the 7α-hydroxy group onto cholesterol by cytochrome P450 7A1, and the second step is the oxidation and isomerization of the 3-hydroxy group and the Δ5,6-double bond by 3β-hydroxy steroid dehydrogenase to yield 7α-Hydroxy-4-cholesten-3-one. The deletion of the gene that expresses P450 27A1, which is found downstream in the bile acid pathway, results in the accumulation of the precursor, 7α-Hydroxy-4-cholesten-3-one.
7α-Hydroxy-4-cholesten-3-one strongly relates to the hepatic enzymatic activity of CYP7A1 at steady-state conditions as well as during the rapid diurnal changes that occur in the rat. That serum 7α-Hydroxy-4-cholesten-3-one has a pronounced diurnal rhythm.
7-羟基-4-胆甾烯-3-酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-113259 | 7-羟基-4-胆甾烯-3-酮 | 3862-25-7 | 1mg | 3500 |
