Metronidazolehydrochloride

Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application[1][2][3][4].

ChEBI: A hydrochloride salt resulting from the mixture of equimolar amounts of metronidazole and hydrogen chloride.

Metronidazole is a nitro-5-imidazole compound with antiprotozoal and antibacterial properties. Topical exposure may induce allergic contact dermatitis. Sensitization is mainly observed with the treatment of rosacea and rarely occurs from handling of tablets in nurses. Systemic intake may provoke fixed drug eruption.

[1] Scully BE. Metronidazole. Med Clin North Am. 1988 May;72(3):613-21. DOI:10.1016/s0025-7125(16)30761-1
[2] Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ). PLoS One. 2016 Jul 29;11(7):e0155390. DOI:10.1371/journal.pone.0155390
[3] Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10. DOI:10.1016/j.neuro.2020.03.002
[4] Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19(8):2418. DOI:10.3390/ijms19082418