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Guanosine 5'-triphosphate trisodium salt

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Guanosine 5'-triphosphate trisodium salt Basic information
Guanosine 5'-triphosphate trisodium salt Chemical Properties
  • storage temp. -20°C
  • solubility H2O: 50 mg/mL
  • form powder
  • color white
  • optical activity[α]20/D 24±2°, c = 1% in 0.5 M Na2HPO4
  • BRN 4113439
  • CAS DataBase Reference36051-31-7(CAS DataBase Reference)
Safety Information
Guanosine 5'-triphosphate trisodium salt Usage And Synthesis
  • Uses
    Guanosine 5′-triphosphate sodium salt solution has been used for reconstituting transducin during purification of transducin.
  • General Description
    GTP is supplied as the disodium salt in crystal form.
  • Biochem/physiol ActionsGTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
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