NEUROPEPTIDE S (HUMAN)

Product NameNEUROPEPTIDE S (HUMAN)
CAS412938-67-1
MFC93H155N31O28S
MW2187.48
EINECS
MOL File412938-67-1.mol

Chemical Properties

Density	1.49±0.1 g/cm3(Predicted)
form	Solid
color	White to off-white
Sequence	Ser-Phe-Arg-Asn-Gly-Val-Gly-Thr-Gly-Met-Lys-Lys-Thr-Ser-Phe-Gln-Arg-Ala-Lys-Ser

Usage And Synthesis

Uses

Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research[1].

Biological Activity

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

in vitro

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC ₅₀ of 6.7 ± 2.4 nM, the binding of [ ^{125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K _d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ ^125I I] Y10-NPS, [ ^125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC ₅₀ = 0.42 ± 0.12 nM).}

in vivo

Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

Animal Model:	Male C57Bl/6 mice
Dosage:	0.1 nM, 1 nM
Administration:	Intracerebroventricular (icv) injection
Result:	Increased locomotor activity and promoted wakefulness.

target

EC50: 9.4 nM (neuropeptide S receptor)

References

[1] Xu YL, et al. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects.Neuron. 2004 Aug 19;43(4):487-97. DOI:10.1016/j.neuron.2004.08.005

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