2(1H)-Pyrimidinone, 5-fluoro-3,4-dihydro-4-imino-3-methyl-1-[(4-methylphenyl)sulfonyl]-

Information of the production of flumetylsulforim is not available in open literature, but its manufacture generally start with preparing the substituted benzyl or phenyl precursor that carries the sulfonyl functionality; this is typically achieved by chlorosulfonation or by coupling a pre-formed sulfonyl chloride with the appropriate aromatic ring under controlled conditions. That intermediate is then reacted with the imide forming fragment, usually introduced through a cyclisation step involving a protected amine or carbamate, to build the characteristic sulfo¬rimide moiety. The final heterocycle is closed under dehydrating conditions, followed by neutralization, solvent exchange, and crystallisation to isolate the technical-grade active.

A systemic multi-site fungicide with foliar uptake

Fungicide