4-Chloro-2-methoxybenzaldehyde

61072-56-8

124-41-4

53581-86-5

The reaction was carried out with 2-fluoro-4-chlorobenzaldehyde (300 mg, 1.89 mmol) and sodium methanol (3784 μL, 1.89 mmol, methanol solution) with stirring at 50 °C for 3 hours. Upon completion of the reaction, the reaction mixture was concentrated to half of the original volume and subsequently purified by Biotage 25 column chromatography using 5% ethyl acetate/hexane as eluent to finally obtain 4-chloro-2-methoxybenzaldehyde (250 mg, 1.47 mmol, 77.5% yield).