11B-羟孕酮
11B-羟孕酮 性质
| 熔点 | 181～184℃ |
|---|---|
| 沸点 | 487.4±45.0 °C(Predicted) |
| 密度 | 1.15±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于丙酮（少许）、氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.52±0.70(Predicted) |
| 颜色 | 白色至类白色 |
| 水溶解性 | 30.84mg/L(37 ºC) |
11B-羟孕酮 用途与合成方法
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Human Endogenous Metabolite
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11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED 50 of 10 nM and stimulates Ams/ sc in mpkCCD cl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770.
11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.
11B-羟孕酮 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-01-25 | HY-N2337 | 1 mg | 225 | ||
| 2024-01-25 | HY-N2337 | 11B-羟孕酮 | 600-57-7 | 5mg | 450 |
