U-75302

U-75302 is an LTB₄ receptor antagonist with a K_i of 159 nM on guinea pig lung membranes. This activity is specific for the BLT₁ receptor; U-75302 does not antagonize the binding of [³H]-LTB₄ to the human BLT₂ receptor.

U-75302 is a selective leukotriene B4 antagonist.

[1] R C FALCONE  D A. Modulation of ligand binding to leukotriene B4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents.[J]. Journal of Pharmacology and Experimental Therapeutics, 1990, 255 2: 565-571.
[2] ALICE H. LIN. Novel Molecules That Antagonize Leukotriene B4 Binding to Neutrophils[J]. Annals of the New York Academy of Sciences, 1988, 524 1: 196-200. DOI: 10.1111/j.1749-6632.1988.tb38542.x
[3] S WANG. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.[J]. The Journal of Biological Chemistry, 2000, 275 52: 40686-40694. DOI: 10.1074/jbc.m004512200
[4] SHIGEYASU TSUDA. Novel Mechanism of Regulation of the 5-lipoxygenase/leukotriene B4 Pathway by High-Density Lipoprotein in Macrophages[J]. Atherosclerosis. Supplements, 2018, 1 1. DOI: 10.1016/j.atherosclerosissup.2018.04.186