Basic information Safety Related Supplier

VIRGINIAMYCIN M1

Basic information Safety Related Supplier
VIRGINIAMYCIN M1 Basic information
VIRGINIAMYCIN M1 Chemical Properties
  • Melting point:165-167℃
  • alpha D20 -218° ( c = 0.34 in ethanol)
  • Boiling point:825.2±65.0 °C(Predicted)
  • Density 1.26±0.1 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility chloroform/methanol: soluble10mg/mL
  • form powder
  • pka13.18±0.70(Predicted)
  • color yellow to tan
Safety Information
  • WGK Germany 3
  • HS Code 29419090
MSDS
VIRGINIAMYCIN M1 Usage And Synthesis
  • Chemical PropertiesLight yellow powder
  • UsesOstreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
  • UsesOstreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.
  • UsesMacrolactone antibiotic. Antibacterial; growth promotant.
  • DefinitionChEBI: A macrolide that is (together with pristinamycin IA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms includ ng methicillin-resistant Staphylococcus aureus.
  • Contact allergensPristinamycin is a systemic antibiotic of the synergistins/ streptogramins class, composed of two subunits: pristinamycin IA and pristinamycin IIA. It induces several types of drug reactions such as maculo-papular exanthema, systemic dermatitis, or acute generalized exanthematous pustulosis. Some patients have been previously skin-sensitized by virginiamycin. Crossreactivity is expected to virginiamycin and to the associated dalfopristin and quinupristin.
  • Contact allergensLike the other streptogramin, pristinamycin, virginiamycin is made of two subunits, virginiamycin S1 and virginiamycin M1. Dermatitis was quite common in people using the formerly available topical virginiamycin. Occupational dermatitis was observed in the pharmaceutical industry, in breeders, and in a surgeon who used topical virginiamycin on postoperative wounds (personal observation).
VIRGINIAMYCIN M1(21411-53-0)Related Product Information
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