SiraMesine, Lu-28-179

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].

Sigma 1 Receptor

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