1H-BENZOTRIAZOLE-1-METHANOL

• Hydrolysis of phenyl esters of a-furoic acid

• Corrosion inhibitor of iron in aerated acidic media
• Reactive oxygen scavenger

• Synthesis of hydroxy-skipped bis-homo-inositols as potential glycosidase inhibitors via Sharpless asymmetric dihydroxylation and substrate-directed anionic hydroxymethylation
• Enantioselective synthesis of aplysin utilizing a palladium-catalyzed addition of an arylboronic acid to an allenic alcohol, followed by Eschenmoser/Claisen rearrangement
• Synthesis of substituted dihydroquinoline carboxylic acids as antitumor and HIV-1 integrase inhibitors
• Gosteli-Claisen rearrangement

95-14-7

50-00-0

28539-02-8

Example 30 Synthesis of 1H-benzotriazole-1-methanol: 10 g (83.94 mmol) of 1H-benzotriazole was dissolved in 6.81 mL (83.94 mmol) of 37% formaldehyde aqueous solution. The temperature of the mixture was adjusted to 25°C under stirring. After 5 minutes of reaction, the mixture was cured. Subsequently, the reaction mixture was cooled to room temperature, filtered and washed with ether. The resulting solid was ground in cold tetrahydrofuran and filtered again (Int.94). Product yield: 94%, melting point: 148-150°C (determined by recrystallization from tetrahydrofuran and ether).