Prostaglandin A1-biotin

Prostaglandin A1 (PGA1) is one of the cyclopentenone prostaglandins, which have well documented antimitotic and antiproliferative effects.1,2 The activity of the compounds in this class, which includes prostaglandins in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. PGA1-biotin is an affinity probe which allows PGA1 to be detected through an interaction with the biotin ligand. PGA1-biotin was designed to allow PGA1 to be detected in complexes with nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone prostaglandins.WARNING This product is not for human or veterinary use.

[1] M D BREGMAN  F L M. Inhibition of human malignant melanoma colony-forming cells in vitro by prostaglandin A1.[J]. Cancer research, 1983, 43 4: 1642-1645.
[2] P M LACAL. Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 2: 1096-1102.
[3] BEATRIZ DÍEZ-DACAL. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.[J]. Cancer research, 2011: 4161-4171. DOI: 10.1158/0008-5472.can-10-3816