17-phenyl trinor Prostaglandin E2 ethyl amide

Chemical Properties

Boiling point	629.4±55.0 °C(Predicted)
Density	1.141±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 100 mg/ml; DMSO: 100 mg/ml; Ethanol: 100 mg/ml; PBS (pH 7.2): 0.5 mg/ml
pka	13.78±0.60(Predicted)

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Animal Model:	8-12 weeks, 15-20 g, C57/BL6 male mice (fivesixths nephrectomy renal fibrosis model)^[1]
Dosage:	0.3 μg/g
Administration:	I.p.; three times a week for 12 weeks
Result:	Increased the plasma blood urea nitrogen (BUN) levels and plasma creatinine (Cr) concentration, increased the extracellular matrix and the area of collagen deposition, upregulated the protein of expression of Col1, GRP78, TRPC1 and PERK in 5/6 Nx mice.