The chemical name of (15R)-BiMatoprost is (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-N-ethylheptenamide. The typical preparation method involves using benzoyl Corey lactone as the starting material, followed by oxidation, Wittig-Horner reaction, reduction, and hydrolysis to obtain intermediate IV. This intermediate is then directly reacted with a Wittig reaction to obtain crude (15R)-BiMatoprost. Alternatively, (15R)-BiMatoprost acid V can be obtained first through a Wittig reaction, followed by esterification and ammonolysis to obtain crude (15R)-BiMatoprost. Finally, the crude product is purified to obtain the final (15R)-BiMatoprost product.
