N-[3-(Bromomethyl)benzyl]carbamic acid tert-butyl ester

226070-69-5

220364-34-1

General procedure for the synthesis of tert-butyl 3-(bromomethyl)benzylcarbamate from tert-butyl (3-hydroxymethyl-benzyl)-carboxylate: Boc-aminomethylbenzyl alcohol (237 mg), triphenylphosphine (485 mg), and carbon tetrabromide (491 mg) were dissolved in dichloromethane (10 mL) and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction solution was concentrated. The crude product was purified by silica gel column chromatography to afford the target product tert-butyl 3-(bromomethyl)benzylcarbamate (200 mg, 67% yield).