N-[3,5-Bis(trifluoromethyl)phenyl]-
N′-[(8
a,9
S)-6′-methoxy-9-cinchonanyl]thiourea is a bifunctional cinchona organocatalyst, which can be used to synthesize:
- Stereoselective diaryl(nitro)butanone via enantioselective Michael addition of nitromethane to chalcones.
- Enantioselective β-amino acids via asymmetric Mannich reaction of malonates with aryl and alkyl imines.
- The synthesis of 3-indolylmethanamines by the reaction of indoles with imines via asymmetric Friedel-Crafts reaction.
- The enantioselective conjugate addition of active methylene compounds to enones to obtain the corresponding addition products.
