8-Bromo-[1,2,4]thiazo[1,5-a]pyridine-2-amine is a pyridine derivative that can be used as a pharmaceutical synthesis intermediate for pharmaceutical synthesis and experimental research.
The general procedure for the synthesis of 2-amino-8-bromo[1,2,4]triazolo[1,5-a]pyridine from compound (CAS:1124383-00-1) is as follows:
1. Dissolution step: Methanol (MeOH, 300 mL), hydroxylamine hydrochloride (62.83 g, 904 mmol) and diisopropylethylamine (DIPEA, 694 mL, 543 mmol) were added to a solution of Intermediate 50 (55 g, 181 mmol) in ethanol (EtOH, 300 mL).
2. Reaction step: the reaction mixture was stirred at room temperature (r.t.) for 6 hours.
3. Post-treatment step: the reaction mixture was concentrated in vacuum and the residue was suspended in diisopropyl ether (DIPE).
4. Separation step: the precipitate was collected by filtration. 5.
5. Yield: 51 37 g of intermediate were obtained in 96% yield.
[1] Patent: WO2013/10904, 2013, A1. Location in patent: Page/Page column 76
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 17, p. 4794 - 4800
[3] Patent: KR2015/77599, 2015, A. Location in patent: Paragraph 0096; 0099-0101
[4] Patent: KR101601354, 2016, B1. Location in patent: Paragraph 0110 - 0112
[5] Patent: US2011/190269, 2011, A1. Location in patent: Page/Page column 66
![8-Bromo-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine Structure](/CAS2/GIF/1124382-72-4.gif)
![ethyl {[(3-broMopyridin-2-yl)aMino]carbonothioyl}carbaMate](/CAS/GIF/1124383-00-1.gif)
![8-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/f6530545-6c09-4b72-8684-19eedd8d2b6f.png)