3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

CDPPB may be used in mGluR5-mediated cell signaling studies.

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide is a glutamate metabotropic (mGluR5) positive allosteric modulator, used in the treatment of Phelan-McDermid syndrome caused by 22qI3 deletion. Studies have shown that 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide suppresses the incre ase of LDH release and caspase-3 activation induced by traumatic neuronal injury.

CDPPB is a glutamate metabotropic mGluR5 positive allosteric modulator.

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