Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg[1].
References
[1] Passafiume M, et al. Sequence analysis of a monoclonal antibody specific for the preS2 region of hepatitis B surface antigen, and the cloning, expression and characterisation of its single-chain Fv construction. FEBS Lett. 1998 Dec 28;441(3):407-12. DOI:10.1016/s0014-5793(98)01581-6