non A4 component of amyloid precursor, PARK1, PARK4, PD1, NACP (Non-a-beta component of Alzheimer disease amyloid, precursor)

Among the familial mutations of α-synuclein in Parkinson′s disease, E46K has the greatest potential to aggregate. This mutation is a 188G-A tran-sition resulting in a Glu46-to-Lys (E46K) substitution in the amino-terminal region of the protein.