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CITRININ

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CITRININ Basic information
CITRININ Chemical Properties
  • Melting point:175°C (dec.)
  • alpha D18 -37.4° (c = 1.15 in alc.)
  • Boiling point:313.38°C (rough estimate)
  • Density 1.37
  • refractive index 1.4560 (estimate)
  • Flash point:2℃
  • storage temp. 2-8°C
  • pka1.52±0.60(Predicted)
  • form Crystalline Powder or Flakes
  • color Yellow
  • Merck 13,2351
  • BRN 5282243
  • CAS DataBase Reference518-75-2(CAS DataBase Reference)
  • IARC3 (Vol. 40, Sup 7) 1987
  • EPA Substance Registry SystemCitrinin (518-75-2)
Safety Information
  • Hazard Codes T
  • Risk Statements 23/24/25-40-36/37/38
  • Safety Statements 26-36/37/39-45-22-7/9
  • RIDADR UN 3462 6.1/PG 3
  • WGK Germany 3
  • RTECS DJ2275000
  • HazardClass 6.1(a)
  • PackingGroup II
  • HS Code 29419090
  • ToxicityLD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)
MSDS
CITRININ Usage And Synthesis
  • Chemical Propertiesyellow crystalline powder or flakes
  • Chemical PropertiesAntimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.
  • UsesAntibiotic substance produced by a white spore aspergilus which has been placed under the species name Aspergillus niveus. Also produced in small quantities by Penicillium citrinum.
  • Usesantibacterial
  • UsesCitrinin is a quinonemethine mycotoxin produced by diverse fungi including Aspergillus and Penicillium. Citrinin has been extensively investigate, and is a potent nephrotoxin with hepatoxic and teratogenic activity. Citrinin is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption of mitochondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity.
  • Potential ExposureSpecific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.
  • ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
CITRININ(518-75-2)Related Product Information
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