N6-Benzyladenosine-5'-O-triphosphate (sodium salt)

N6-Benzyladenosine-5'-O-triphosphate is an N-phenyl-substituted derivative of ATP and a ligand used for bump and hole, a technique to study single protein isoforms when familial homology would interfere with other isoform-selective approaches.1 It is 7-fold selective for inhibiting the ATP binding and ATPase activity of myosin light chain (MLC) containing a tyrosine-to-glycine substitution at position 61 (MLCY61G) over the wild-type enzyme. N6-Benzyladenosine-5'-O-triphosphate has been used to develop a technique to identify substrates of the programmed cell death-suppressor kinase AvrPto-dependent Pto-interacting protein 3 (Adi3) in tomato plants.2WARNING This product is not for human or veterinary use.

[1] LAUREN N.S. BITTNER. Engineering of the Myosin Viia Nucleotide-Binding Pocket to Create Selective Sensitivity to N6-Modified ADP Analogs[J]. Biophysical journal, 2013, 104 1. DOI: 10.1016/j.bpj.2012.11.3558
[2] ANNA C. NELSON DITTRICH  Timothy P D. An ATP analog-sensitive version of the tomato cell death suppressor protein kinase Adi3 for use in substrate identification[J]. Biochimica et biophysica acta. Proteins and proteomics, 2012, 1824 2: Pages 269-273. DOI: 10.1016/j.bbapap.2011.10.004