2-Nonylquinolin-4(1H)-one-d4

2-Nonylquinolin-4(1H)-one-d4 is intended for use as an internal standard for the quantification of 2-nonylquinolin-4(1H)-one (Item No. 9003627) by GC- or LC-MS. 2-Nonylquinolin-4(1H)-one is a quinolone alkaloid that has been found in P. aeruginosa and has diverse biological activities.1,2,3,4 It reduces infection of Huh7.5 cells by hepatitis C virus (HCV) with an IC50 value of 1.4 µg/ml.1 2-Nonylquinolin-4(1H)-one (50 and 100 µg/ml) is also active against L. gongylophorus, a symbiotic fungus of the agricultural pest A. sexdens (leaf-cutting ant).2 It inhibits activation of nuclear factor of activated T cells (NFAT) induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and the calcium ionophore A23187 (Item No. 11016) in Jurkat cells (IC50 = 3.44 µM), but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50 = >100 µM), in reporter assays.3WARNING This product is not for human or veterinary use.

[1] TUTIK SRI WAHYUNI . Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves[J]. Fitoterapia, 2014, 99: Pages 276-283. DOI: 10.1016/j.fitote.2014.10.011
[2] M. BIAVATTI. Biological Activity of Quinoline Alkaloids from Raulinoa echinata and X-ray Structure of Flindersiamine[J]. Journal of the Brazilian Chemical Society, 2002, 13 1: 66-70. DOI: 10.1590/s0103-50532002000100010
[3] HUI ZI JIN. Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpa.[J]. Biological & pharmaceutical bulletin, 2004, 27 6: 926-928. DOI: 10.1248/bpb.27.926
[4] CATHARINE A. ORTORI. Simultaneous quantitative profiling of N-acyl-l-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MS[J]. Analytical and Bioanalytical Chemistry, 2010, 399 2: 839-850. DOI: 10.1007/s00216-010-4341-0